Louis is the host of Inside City Hall, a program about New York City politics that airs nightly on NY1. Prior to joining NY1 in November 2010, Louis was a columnist for the New York Daily News, where he also served on the editorial board. On June 23, 2008, Louis became host of the Morning Show, a three-hour talk program on radio station WWRL; in 2009 he was succeeded by Mark Riley. In November 2010 The Village Voice named him the city's best newspaper columnist and radio show host.
Louis is the Director of the Urban Reporting program at the City University of New York's Graduate School of Journalism. He is also a CNN contributor and has made frequent appearances on Lou Dobbs Tonight and other CNN news programs.
Formerly an associate editor of The New York Sun, Louis joined the Daily News in 2004 and for many years wrote a column, "Commerce and Community", for Our Time Press, which is published weekly and based in the Bedford-Stuyvesant neighborhood of Brooklyn.
He has taught college courses and co-founded the Central Brooklyn Federal Credit Union, and was once named by New York Magazine as one of "10 New Yorkers Making a Difference", "with energy, vision and independent thinking." He has also run for political office, coming in third in a race for the New York City Council's 35th District in 1997. 
Louis holds a B.A. in government from Harvard, an M.A. in political science from Yale, and a J.D. from Brooklyn Law School. He was raised in New Rochelle and lives in Crown Heights, Brooklyn, with his wife, Juanita Scarlett, and their son.